Management Scientific Board Quality Assurance Unit Chemistry Department Formulation Manufacturing Department Minisynthesis Department Pharmacology Department Pharmacy Department Pilot Plant Department Quality Control and Research Analytics Department


  ORGANIZATION DRAFT > MINISYNTHESIS DEPARTMENT

Reactor
Reactor 100 dm3

The Minisynthesis Department develops new processes for the manufacturing of active pharmaceutical ingredients (API). It also produces several APIs on a small scale, from grams to kilograms. The production takes place in dedicated laboratories and is performed in accordance with GMP rules. Research activities include mainly scaling, optimizing and validation of manufacturing processes. Technologies developed in the Minisynthesis Department are used in our production plant or transferred to other pharmaceutical companies. Our staff is experienced in using aggressive reagents like hydrogen chloride, hydrogen fluoride, sulfur dioxide, alkyllithium reagents and Grignard reagents.

Our services include:

  1. Development of API manufacturing processes.
  2. Production of API in the "kilolab" scale on contract bases.
  3. Supplying certified active ingredients (API) produced in the Minisynthesis Department:
        0.6 MB Alfacalcidol - Certificate of Suitability
        0.2 MB Calcitriol - Certificate of Suitability

Key equipment of the Minisynthesis Department:

  • Glass reactors from 1 to 100 dm3 capacity
  • Enamel reactors 200 and 600 dm3
  • Filters, centrifuges and driers
  • Rotary evaporators from 2 to 203
  • Preparative HPLC
  • Ozone generator
  • Photochemical reactors

Laboratory Laboratory Photochemical reaction set Photochemical reaction set

Staff:

  • Scientific staff - 18 persons (including 9 Ph.Ds)
  • Technical staff - 12 persons

 Head:  Jerzy Winiarski, Ph.D.
 Phone:  (+48 22) 456 39 41
 Fax:  (+48 22) 456 38 38
 E-mail: